PoplarV1, Main, Exploration, bibRecord, 000F83

Conserved noncoding sequences conserve biological networks and influence genome evolution.

Identifieur interne : 000F83 ( Main/Exploration ); précédent : 000F82; suivant : 000F84

Conserved noncoding sequences conserve biological networks and influence genome evolution.

Auteurs : Jianbo Xie [République populaire de Chine] ; Kecheng Qian [République populaire de Chine] ; Jingna Si [République populaire de Chine] ; Liang Xiao [République populaire de Chine] ; Dong Ci [République populaire de Chine] ; Deqiang Zhang [République populaire de Chine]

Source :

Heredity [ 1365-2540 ] ; 2018.

RBID : pubmed:29396421

Descripteurs français

English descriptors

KwdEn :
- Adaptation, Physiological (MeSH), Conserved Sequence (genetics), DNA Methylation (MeSH), Evolution, Molecular (MeSH), Gene Duplication (MeSH), Gene Frequency (MeSH), Genome, Plant (genetics), Genomics (MeSH), Oligonucleotide Array Sequence Analysis (MeSH), Populus (genetics), Populus (physiology), Regulatory Sequences, Nucleic Acid (genetics), Sequence Analysis, DNA (MeSH).
MESH :
- genetics : Conserved Sequence, Genome, Plant, Populus, Regulatory Sequences, Nucleic Acid.
- physiology : Populus.
- Adaptation, Physiological, DNA Methylation, Evolution, Molecular, Gene Duplication, Gene Frequency, Genomics, Oligonucleotide Array Sequence Analysis, Sequence Analysis, DNA.

Abstract

Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection remains limited. Here, we used a combination of DNA methylome analysis, microarray expression analyses, and functional annotation to study these sequences in the model tree Populus trichocarpa. Methylation in CG contexts and non-CG contexts was lower in CNSs, particularly CNSs in the 5'-upstream regions of genes, compared with other sites in the genome. We observed that CNSs are enriched in genes with transcription and binding functions, and this also associated with syntenic genes and those from whole-genome duplications, suggesting that cis-regulatory sequences play a key role in genome evolution. We detected a significant positive correlation between CNS number and protein interactions, suggesting that CNSs may have roles in the evolution and maintenance of biological networks. The divergence of CNSs indicates that duplication-degeneration-complementation drives the subfunctionalization of a proportion of duplicated genes from whole-genome duplication. Furthermore, population genomics confirmed that most CNSs are under strong purifying selection and only a small subset of CNSs shows evidence of adaptive evolution. These findings provide a foundation for future studies exploring these key genomic features in the maintenance of biological networks, local adaptation, and transcription.

DOI: 10.1038/s41437-018-0055-4
PubMed: 29396421
PubMed Central: PMC5889393

Affiliations:

République populaire de Chine

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<term>Conserved Sequence (genetics)</term>
<term>DNA Methylation (MeSH)</term>
<term>Evolution, Molecular (MeSH)</term>
<term>Gene Duplication (MeSH)</term>
<term>Gene Frequency (MeSH)</term>
<term>Genome, Plant (genetics)</term>
<term>Genomics (MeSH)</term>
<term>Oligonucleotide Array Sequence Analysis (MeSH)</term>
<term>Populus (genetics)</term>
<term>Populus (physiology)</term>
<term>Regulatory Sequences, Nucleic Acid (genetics)</term>
<term>Sequence Analysis, DNA (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique (MeSH)</term>
<term>Analyse de séquence d'ADN (MeSH)</term>
<term>Duplication de gène (MeSH)</term>
<term>Fréquence d'allèle (MeSH)</term>
<term>Génome végétal (génétique)</term>
<term>Génomique (MeSH)</term>
<term>Méthylation de l'ADN (MeSH)</term>
<term>Populus (génétique)</term>
<term>Populus (physiologie)</term>
<term>Séquence conservée (génétique)</term>
<term>Séquences d'acides nucléiques régulatrices (génétique)</term>
<term>Séquençage par oligonucléotides en batterie (MeSH)</term>
<term>Évolution moléculaire (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conserved Sequence</term>
<term>Genome, Plant</term>
<term>Populus</term>
<term>Regulatory Sequences, Nucleic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome végétal</term>
<term>Populus</term>
<term>Séquence conservée</term>
<term>Séquences d'acides nucléiques régulatrices</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Populus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term>
<term>DNA Methylation</term>
<term>Evolution, Molecular</term>
<term>Gene Duplication</term>
<term>Gene Frequency</term>
<term>Genomics</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adaptation physiologique</term>
<term>Analyse de séquence d'ADN</term>
<term>Duplication de gène</term>
<term>Fréquence d'allèle</term>
<term>Génomique</term>
<term>Méthylation de l'ADN</term>
<term>Séquençage par oligonucléotides en batterie</term>
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<front><div type="abstract" xml:lang="en">Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection remains limited. Here, we used a combination of DNA methylome analysis, microarray expression analyses, and functional annotation to study these sequences in the model tree Populus trichocarpa. Methylation in CG contexts and non-CG contexts was lower in CNSs, particularly CNSs in the 5'-upstream regions of genes, compared with other sites in the genome. We observed that CNSs are enriched in genes with transcription and binding functions, and this also associated with syntenic genes and those from whole-genome duplications, suggesting that cis-regulatory sequences play a key role in genome evolution. We detected a significant positive correlation between CNS number and protein interactions, suggesting that CNSs may have roles in the evolution and maintenance of biological networks. The divergence of CNSs indicates that duplication-degeneration-complementation drives the subfunctionalization of a proportion of duplicated genes from whole-genome duplication. Furthermore, population genomics confirmed that most CNSs are under strong purifying selection and only a small subset of CNSs shows evidence of adaptive evolution. These findings provide a foundation for future studies exploring these key genomic features in the maintenance of biological networks, local adaptation, and transcription.</div>
</front>
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<DateCompleted><Year>2019</Year>
<Month>06</Month>
<Day>03</Day>
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<Month>03</Month>
<Day>06</Day>
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<ArticleTitle>Conserved noncoding sequences conserve biological networks and influence genome evolution.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41437-018-0055-4</ELocationID>
<Abstract><AbstractText>Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection remains limited. Here, we used a combination of DNA methylome analysis, microarray expression analyses, and functional annotation to study these sequences in the model tree Populus trichocarpa. Methylation in CG contexts and non-CG contexts was lower in CNSs, particularly CNSs in the 5'-upstream regions of genes, compared with other sites in the genome. We observed that CNSs are enriched in genes with transcription and binding functions, and this also associated with syntenic genes and those from whole-genome duplications, suggesting that cis-regulatory sequences play a key role in genome evolution. We detected a significant positive correlation between CNS number and protein interactions, suggesting that CNSs may have roles in the evolution and maintenance of biological networks. The divergence of CNSs indicates that duplication-degeneration-complementation drives the subfunctionalization of a proportion of duplicated genes from whole-genome duplication. Furthermore, population genomics confirmed that most CNSs are under strong purifying selection and only a small subset of CNSs shows evidence of adaptive evolution. These findings provide a foundation for future studies exploring these key genomic features in the maintenance of biological networks, local adaptation, and transcription.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Jianbo</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, No. 35, Qinghua East Road, Beijing, 100083, P. R. China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, No. 35, Qinghua East Road, Beijing, 100083, P. R. China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Qian</LastName>
<ForeName>Kecheng</ForeName>
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<ArticleIdList><ArticleId IdType="pubmed">29396421</ArticleId>
<ArticleId IdType="doi">10.1038/s41437-018-0055-4</ArticleId>
<ArticleId IdType="pii">10.1038/s41437-018-0055-4</ArticleId>
<ArticleId IdType="pmc">PMC5889393</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nat Genet. 2014 Oct;46(10):1089-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25151358</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2013 Jan;41(Database issue):D1152-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23180799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>New Phytol. 2017 Jan;213(1):206-219</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27277139</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Heredity (Edinb). 2013 Feb;110(2):97-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23169563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2012 May 20;44(6):725-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22610118</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2014 May;31(5):1066-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24577842</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2011 Jun 1;27(11):1571-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21493656</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 Oct 10;302(5643):249-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12934013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol Evol. 2012;4(5):641-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22505575</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Physiol. 2016 Aug;171(4):2586-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27261064</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2004 Dec 12;20(18):3643-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15247098</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2006 Mar;23(3):530-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16280543</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2008 Dec;18(12):1944-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18832442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5454-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15800040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Algorithms Mol Biol. 2011 Nov 24;6:26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22115189</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2015 Dec;32(12):3226-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26374232</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Evol Biol. 2009 Aug 15;9:203</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19682388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2007 May;17(5):545-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17387144</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2003 Jan 1;31(1):258-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12519996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Genet. 2007 Mar;8(3):206-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17304246</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Plant Biol. 2010 Dec 19;10:281</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21167067</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>New Phytol. 2012 Jan;193(1):241-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21955124</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W116-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15980438</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2012 Mar 01;7(3):562-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22383036</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2012 Nov;29(11):3541-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22734049</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 May 28;304(5675):1321-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15131266</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant J. 2001 Jan;25(1):1-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11169177</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2006 Mar;4(3):e72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16494531</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2014 Jul;26(7):2729-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24989046</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2015 Jul;32(7):1767-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25750178</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol Evol. 2013;5(12):2330-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24259317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biotechniques. 2003 Feb;34(2):374-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12613259</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2001 Jul;158(3):1227-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11454770</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 1999 Apr;151(4):1531-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10101175</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Biotechnol. 2005 Jan;23(1):137-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15637633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2011 Jul;39(Web Server issue):W155-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21622958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2009 Nov 19;462(7271):315-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19829295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2004 Jul;16(7):1667-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15208399</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2004 Jul;16(7):1679-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15208398</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Genet. 2014;15 Suppl 1:S9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25080211</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2011 Aug 1;27(15):2156-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21653522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2006 Feb;38(2):223-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16380714</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Methods. 2012 Mar 04;9(4):357-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22388286</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2012 Oct;24(10):3949-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23110901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2005 Jul;15(7):901-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15965027</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Genet. 2013 Aug;45(8):891-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23817568</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genetics. 2013 Sep;195(1):205-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23821598</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2009 Nov;19(11):2036-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19704032</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):780-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11792834</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2012 Jan;22(1):95-105</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21974993</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Biol. 2005 Jul 1;283(1):1-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15907831</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Plant Biol. 2009 Apr;12(2):126-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19249238</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2006 Apr;4(4):e45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16602820</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19458158</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Biol. 2014 Mar 15;387(2):214-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24440152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol. 2006;7(7):R56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16859531</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2017 Jan 4;45(D1):D1040-D1045</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27924042</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Res. 2001 Oct;11(10):1625-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11591639</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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</country>
</list>
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Conserved noncoding sequences conserve biological networks and influence genome evolution.

Conserved noncoding sequences conserve biological networks and influence genome evolution.

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